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KMID : 1103720150730030147
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Journal of the Korean Society of Radiology
2015 Volume.73 No. 3 p.147 ~ p.157
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Quantitative CT Assessment in Chronic Obstructive Pulmonary Disease Patients: Comparison of the Patients with and without Consistent Clinical Symptoms and Pulmonary Function Results
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Nam Bo-Da
Hwang Jeong-Hwa
Lee Young-Mok
Park Jai-Soung
Cho Sung-Sik
Kim Yong-Bae
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Abstract
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Purpose : We compared the clinical and quantitative CT measurement parameters between chronic obstructive pulmonary disease (COPD) patients with and without consistent clinical symptoms and pulmonary function results.
Materials and Methods : This study included 60 patients having a clinical diagnosis of COPD, who underwent chest CT scan and pulmonary function tests. These 60 patients were classified into typical and atypical groups, which were further sub-classified into 4 groups, based on their dyspnea score and the result of pulmonary function tests [typical 1: mild dyspnea and pulmonary function impairment (PFI); typical 2: severe dyspnea and PFI; atypical 1: mild dyspnea and severe PFI; atypical 2: severe dyspnea and mild PFI]. Quantitative measurements of the CT data for emphysema, bronchial wall thickness and air-trapping were performed using software analysis. Comparative statistical analysis was performed between the groups.
Results : The CT emphysema index correlated well with the results of the pulmonary functional test (typical 1 vs. atypical 1, p = 0.032), and the bronchial wall area ratio correlated with the dyspnea score (typical 1 vs. atypical 2, p = 0.033). CT air-trapping index also correlated with the results of the pulmonary function test (typical 1 vs. atypical 1, p = 0.012) and dyspnea score (typical 1 vs. atypical 2, p = 0.000), and was found to be the most significant parameter between the typical and atypical groups.
Conclusion : Quantitative CT measurements for emphysema and airways correlated well with the dyspnea score and pulmonary function results in patients with COPD. Air-trapping was the most significant parameter between the typical vs. atypical group of COPD patients.
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KEYWORD
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Chronic Obstructive Pulmonary Disease, Emphysema, Air-Trapping, CT Quantification
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